Research carried out by Procter&Gamble and London School of Pharmacy shows that Aqueous Cream prescribed by many GPs is bad for eczema and atopic dermatitis.
Aqueous cream BP contains sodium layrul sulphate, a known irritant, that should not to be used on damaged skin!
Aqueous Cream BP is frequently prescribed for patients with eczema and is known to induce sensitivity in certain patients and also to decrease the thickness of the stratum corneum (SC). The aim of the present study was to investigate changes in corneocyte size, corneocyte maturity, selected protease activities, protein content and transepidermal water loss (TEWL) in normal forearm skin after a 28-day twice daily application of Aqueous Cream BP.
- Results indicate that corneocyte maturity and size decreased with increasing number of tape strips, and were significantly lower in treated sites compared with untreated sites.
- Protease activity and TEWL values were higher (P < 0·05) for the treated sites compared with untreated sites.
- The amount of protein removed from deeper layers of treated sites was significantly lower than from untreated sites.
- Treatment with Aqueous Cream BP is associated with increased desquamatory and inflammatory protease activity.
- in corneocyte maturity and size are also indicative of accelerated skin turnover induced by chronic application of this emollient.
- These findings question firmly the routine prescription of this preparation as a moisturizer in patients with atopic dermatitis!